Direct synthesis of sensitive selenocysteine peptides by the Ugi reaction.
نویسندگان
چکیده
Ammonia and selenoaldehydes are both problematic components in Ugi reactions. Here we report the efficient direct multicomponent synthesis of sensitive selenocysteine peptides without the use of convertible (protected) primary amines, including suitable deprotection protocols for selenols.
منابع مشابه
One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water.
Selenocysteine containing peptoids and peptide-peptoid conjugates were synthesized by combinatorial Ugi-MCRs (multicomponent reactions) in water: for the first time, an acetal (selenoacetal 2a) was used in Ugi-MCR to furnish selenocysteine peptoids in one step as model compounds for selenocysteine peptides and proteins.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 47 شماره
صفحات -
تاریخ انتشار 2012